controls e07305m  (Cusabio)

Journal: Molecular Medicine

Article Title: Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice

doi: 10.1186/s10020-025-01282-7

Figure Lengend Snippet: Inhibition of RAS protected against vascular dysfunction induced by Tac in dorsal pancreatic arteries. A ACh-induced vasorelaxation in dorsal pancreatic arteries from mice treated with vehicle, Tac and/or Val ( N = 6). B Ang II, ( C ) PE and ( D ) U46619-induced vasoconstriction in dorsal pancreatic arteries from mice treated with vehicle, Tac and/or Val ( N = 6). E The change in pancreatic blood flow in mice treated with vehicle, Tac and/or Val ( N = 6). (* p < 0.05 versus Control, # p < 0.05 versus Tac). Statistical differences were calculated by two-way ANOVA followed by Dunnett’s post hoc test ( A - D ). Statistical differences were calculated by one-way ANOVA followed by Turkey’s post hoc test ( E )

Article Snippet: Plasma Ang II and renin levels were measured by the Mouse Ang II ELISA Kit (E-EL-M2612, Elabscience Biotechnology, China) and the Mouse REN (Renin) ELISA Kit (E-EL-M0061, Elabscience Biotechnology, China), respectively, according to the manufacturer’s instructions.

Techniques: Inhibition, Control

Journal: Molecular Medicine

Article Title: Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice

doi: 10.1186/s10020-025-01282-7

Figure Lengend Snippet: Administration of Tac activate systemic RAS. The changes in plasma renin ( A ) and Ang II ( B ) levels in mice treated with vehicle or Tac ( N = 5). C The protein levels of renin in kidney were detected by western blot ( N = 4). D Representative photomicrographs, and quantification of renin expression in kidney sections ( N = 5). (* p < 0.05 versus Control). Statistical differences were calculated by the paired T-test

Article Snippet: Plasma Ang II and renin levels were measured by the Mouse Ang II ELISA Kit (E-EL-M2612, Elabscience Biotechnology, China) and the Mouse REN (Renin) ELISA Kit (E-EL-M0061, Elabscience Biotechnology, China), respectively, according to the manufacturer’s instructions.

Techniques: Clinical Proteomics, Western Blot, Expressing, Control

Journal: Molecular Medicine

Article Title: Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice

doi: 10.1186/s10020-025-01282-7

Figure Lengend Snippet: Inhibition of RAS protected against vascular dysfunction in renal arteries induced by Tac. A ACh-induced vasorelaxation in renal interlobar arteries from mice treated with vehicle, Tac and/or Val ( N = 6). ( B ) Ang II, ( C ) PE and ( D ) U46619-induced vasoconstriction in renal interlobar arteries from mice treated with vehicle, Tac and/or Val ( N = 6). E The change in renal blood flow in mice treated with vehicle, Tac and/or Val ( N = 6). (* p < 0.05 versus Control, # p < 0.05 versus Tac). Statistical differences were calculated by two-way ANOVA followed by Dunnett’s post hoc test ( A - D ). Statistical differences were calculated by one-way ANOVA followed by Turkey’s post hoc test ( E )

Article Snippet: Plasma Ang II and renin levels were measured by the Mouse Ang II ELISA Kit (E-EL-M2612, Elabscience Biotechnology, China) and the Mouse REN (Renin) ELISA Kit (E-EL-M0061, Elabscience Biotechnology, China), respectively, according to the manufacturer’s instructions.

Techniques: Inhibition, Control